Supplements and Longevity: What Works and What Doesn’t

Marshall Medical Group • April 8, 2025

In the quest for a longer, healthier life, many individuals turn to supplements in hopes of slowing the aging process, enhancing vitality, and promoting longevity. From NAD+ boosters to omega-3 fatty acids, there are countless options available, each claiming to provide significant benefits for aging. However, with so many choices on the market, it can be difficult to determine which supplements truly offer benefits and which ones are just hype.


In this blog post, we’ll review some of the most popular supplements touted for their anti-aging properties, including NAD+ boosters, omega-3 fatty acids, and antioxidants. We’ll also provide evidence-based insights into which supplements actually have scientific backing for longevity and which may fall short.



1. NAD+ Boosters: The Fountain of Youth?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body and plays a crucial role in energy production, DNA repair, and cellular maintenance. As we age, NAD+ levels naturally decline, which has been linked to several age-related health issues, including reduced energy, cognitive decline, and increased risk of chronic diseases.


The Promise of NAD+ Supplements

NAD+ boosters, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have gained significant popularity in recent years for their purported ability to increase NAD+ levels, potentially slowing down the aging process. These supplements are believed to help rejuvenate cells, improve energy metabolism, and reduce age-related inflammation.


Evidence-Based Insights

While there is promising research in animal models, the evidence in humans is still emerging. Studies on NAD+ boosters have shown some potential benefits, such as:


  • Improved mitochondrial function: NAD+ plays a key role in cellular energy production, and boosting its levels may help improve energy metabolism.
  • DNA repair and longevity: Animal studies suggest that increasing NAD+ may promote DNA repair and protect against age-related cellular damage.
  • Cognitive health: Some early research suggests that NAD+ supplementation could help with cognitive function and prevent age-related neurodegeneration.



Omega-3 Fatty Acids: The Heart-Healthy Supplement

Omega-3 fatty acids are essential fats that our bodies cannot produce on their own, so we must obtain them from food sources or supplements. These fats, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are well-known for their heart health benefits and are commonly found in fatty fish like salmon, mackerel, and sardines.


The Promise of Omega-3 Supplements for Longevity

Omega-3 fatty acids have been linked to numerous health benefits, including reduced inflammation, improved heart health, and better cognitive function. Given these well-established effects, omega-3s are often touted as an important supplement for promoting longevity and healthy aging.


Evidence-Based Insights

The evidence supporting omega-3 supplementation is robust, with numerous studies showing the following benefits for aging:



  • Cardiovascular health: Omega-3s help reduce the risk of heart disease by lowering triglycerides, reducing blood pressure, and improving overall heart health. They have also been shown to reduce the risk of heart attacks and strokes.
  • Anti-inflammatory effects: Chronic inflammation is a key driver of aging and age-related diseases. Omega-3s have anti-inflammatory properties that can help reduce inflammation in the body, lowering the risk of conditions like arthritis and cognitive decline.
  • Cognitive health: DHA, in particular, is essential for brain health, and studies suggest that omega-3 supplementation may help preserve cognitive function and reduce the risk of dementia and Alzheimer’s disease in older adults.
  • Telomere preservation: Some research has suggested that omega-3s may help protect telomeres, the protective caps on chromosomes that shorten with age. Longer telomeres are associated with greater longevity.


Given the wealth of evidence supporting their benefits, omega-3 fatty acids are widely considered one of the most effective supplements for promoting longevity. To maximize their benefits, consider incorporating omega-3-rich foods into your diet or taking a high-quality omega-3 supplement.

3. Antioxidants: Protecting Against Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules) and antioxidants in the body. Free radicals can cause cellular damage, contributing to aging and various chronic diseases. Antioxidants, such as vitamin C, vitamin E, selenium, and coenzyme Q10 (CoQ10), help neutralize free radicals, potentially slowing down the aging process.


The Promise of Antioxidant Supplements for Longevity

Given the role of oxidative stress in aging, antioxidant supplements are often marketed as a way to combat cellular damage, reduce inflammation, and promote longevity. Many antioxidant-rich supplements claim to protect against age-related diseases like cancer, heart disease, and neurodegeneration.


Evidence-Based Insights

While the concept of antioxidants in preventing aging is compelling, the evidence is mixed when it comes to antioxidant supplementation:


  • Vitamin C and E: These vitamins have strong antioxidant properties, and while they are essential for overall health, studies on their effectiveness in slowing aging or preventing chronic diseases through supplementation have yielded inconsistent results. In some cases, high-dose antioxidant supplements have even been linked to adverse effects, such as an increased risk of certain cancers.
  • Coenzyme Q10 (CoQ10): CoQ10 is a powerful antioxidant that plays a key role in energy production. Studies suggest that CoQ10 supplementation may help improve mitochondrial function and reduce oxidative damage, which could slow down the aging process. CoQ10 has also been studied for its potential to improve heart health and cognitive function in aging individuals.
  • Selenium: Selenium is another antioxidant that has been linked to improved immune function and may help protect against oxidative damage. Some studies have suggested that selenium supplementation may lower the risk of certain cancers and heart disease, although more research is needed.

Conclusion: What Works for Longevity?

As always, it’s important to consult with a healthcare provider before starting any new supplement regimen, as supplements can interact with medications or underlying health conditions.

If you're looking for personalized advice on supplements for longevity or need guidance on developing a wellness plan, our team is here to help. Contact us today to learn more about how you can improve your health and promote longevity through diet, supplements, and lifestyle changes.

Biohacking: Taking Control of Your Own Biology - Dr. John Mullins 12 Pillar Approach to The Core Premise of Lifestyle Medicine

By Marshall Medical Group • April 11, 2025
Optimize Your Health, Energy, and Longevity with Data-Driven Wellness In today’s fast-paced world, more people are looking for ways to optimize their health, boost energy, and extend their lifespan—not just by treating illness, but by proactively upgrading the way their body and mind function. That’s where biohacking comes in. At Marshall Medical Group, we help our patients take control of their own biology through a personalized, science-backed approach to wellness. From advanced diagnostics and targeted supplements to customized fitness and nutrition plans, biohacking is about leveraging data and innovation to help you look, feel, and perform at your best—every day.  Whether you're new to the concept or already tracking your biometrics, this guide will help you understand what biohacking is, how it works, and how concierge medicine can support you in achieving peak health.

How Concierge Medicine Improves Work-Life Balance for Busy Professionals

By Marshall Medical Group • April 10, 2025
As a busy executive or high-net-worth individual, your time is your most valuable asset. Between demanding work schedules, travel, and personal commitments, managing your health can often take a backseat—leading to unnecessary stress, wasted time, and frustration. Fortunately, concierge medicine offers a smarter, more efficient healthcare solution that can enhance both your work-life balance and your overall well-being. At Marshall Medical Group, we understand the unique challenges of balancing a high-powered career with personal health. With personalized care that focuses on convenience, efficiency, and high-touch service, concierge medicine provides an elevated healthcare experience tailored to your needs. Let’s explore how concierge medicine can help you reduce stress, streamline your healthcare, and ultimately reclaim your time and peace of mind.

Travel Medicine for the Modern Executive: Health Tips for the Frequent Traveler

By Marshall Medical Group • April 10, 2025
For today’s business executives and frequent flyers, travel is a way of life. But with long flights, changing time zones, unfamiliar food, and varying healthcare standards around the world, staying healthy on the go can be a challenge. At Marshall Lifestyle Medicine, we offer comprehensive travel medicine services designed specifically for busy professionals. Whether you’re preparing for a trip across the country or halfway around the globe, our concierge care model ensures you have direct access to your physician —anytime, anywhere.  Let’s explore how concierge medicine can support your travel lifestyle and what steps you can take to protect your health while away from home.

Personalized Nutrition and Fitness Plans: How We Help You Stay at Your Best

By Marshall Medical Group • April 10, 2025
True wellness isn’t one-size-fits-all. What works for one person might not work for another—and that’s exactly why personalized nutrition and fitness plans are essential to helping you feel your best and live a longer, healthier life. At Marshall Medical Group, we go beyond basic diet advice and generic exercise recommendations. Through our concierge medicine model , we offer in-depth evaluations and customized wellness plans designed around your body, your goals, and your lifestyle. Whether you're looking to lose weight, build strength, improve energy levels, or support long-term health, we help you create a realistic and sustainable strategy for lasting wellness. 

The Impact of Concierge Medicine on Chronic Disease Management

By Marshall Medical Group • April 10, 2025
Managing a chronic condition takes more than just a few office visits each year—it requires ongoing support, personalized care, and a proactive approach to long-term health. For patients living with diabetes, high blood pressure, heart disease, thyroid disorders, and other chronic conditions , the traditional healthcare model often falls short. At Marshall Medical Group, we’ve seen how concierge medicine transforms the experience and outcomes of chronic disease management . With longer appointments, 24/7 physician access, and custom treatment plans, our concierge patients receive care that’s not only convenient—but far more effective. 

Exclusive Health Screenings and Preventative Care: Stay Ahead of Health Issues

By Marshall Medical Group • April 10, 2025
The Power of Early Detection and Personalized Prevention Through Concierge Medicine One of the most powerful tools in medicine isn’t a new treatment—it’s early detection. Catching health issues before they become problems can save lives, reduce healthcare costs, and help you live longer, healthier, and with greater peace of mind. At Marshall Medical Group, we believe prevention is the best medicine. Through our concierge care model , we offer patients exclusive access to advanced health screenings, personalized risk assessments, and cutting-edge diagnostic tools that go far beyond what’s typically available in a traditional practice. 

The Luxury of 24/7 Access to Your Physician: Why It Matters

By Marshall Medical Group • April 10, 2025
Imagine being able to call or text your doctor directly—even in the evening, on a weekend, or while traveling. No waiting on hold, no answering services, and no unnecessary urgent care visits. This is the reality of 24/7 physician access—a hallmark of concierge medicine and one of the most valued features by our patients at Marshall Medical Group.  In a world where convenience and responsiveness are essential, having around-the-clock access to your physician isn’t just a luxury—it’s a lifesaving advantage.

Exercise for Longevity: Why Movement is Key to a Longer Life

By Marshall Medical Group • April 10, 2025
When it comes to living a long, healthy life, regular exercise is one of the most powerful tools at your disposal. Whether you're in your 30s, 50s, or beyond, staying active plays a crucial role in slowing the aging process, reducing chronic disease risk, and boosting overall well-being . At Marshall Medical Group, we often tell our patients: you don’t need to be an athlete to benefit from movement— just move regularly, and move with purpose. Let’s take a closer look at how physical activity supports healthy aging and which exercises are most effective for promoting longevity.

How Concierge Medicine Can Help You Achieve Optimal Health and Wellness

By Marshall Medical Group • April 10, 2025
In today’s fast-paced world, many people feel like just another number in the healthcare system—quick visits, generic advice, and little time to focus on what really matters: your long-term health and wellness . If you’re looking for a more personalized, proactive approach to healthcare, concierge medicine may be the solution. At Marshall Medical Group, our concierge model is built around one goal— helping you achieve optimal health , not just treat illness. Through longer visits, tailored care plans, and direct access to your physician, concierge medicine provides the foundation for a holistic, preventative approach to your well-being. 

What Is Concierge Medicine? Understanding the Benefits of Personalized Healthcare

By Marshall Medical Group • April 10, 2025
Healthcare should be personal, accessible, and centered on your unique needs. Yet, for many patients, traditional healthcare models fall short—offering rushed visits, long wait times, and limited time with physicians. That’s where concierge medicine comes in. Also known as personalized healthcare or direct primary care , concierge medicine is a growing model that puts the patient-physician relationship back at the center of care. At Marshall Medical Group, we are proud to offer concierge services that provide our patients with an exceptional level of attention, convenience, and peace of mind. 
More Posts