12 Benefits for Perimenopausal and Menopausal Women

Marshall Medical Group • May 19, 2025

Here are 10 potential benefits of hormonal therapy (HT) for perimenopausal women, based on current clinical evidence and expert guidelines:

1. Relieves Hot Flashes and Night Sweats

  • HT is the most effective treatment for vasomotor symptoms, including hot flashes and sleep-disrupting night sweats.

2. Improves Sleep Quality

  • By reducing night sweats and anxiety, HT helps many women sleep better and wake less frequently.

3. Reduces Vaginal Dryness and Discomfort

  • Estrogen therapy restores vaginal tissue elasticity, moisture, and pH balance, relieving dryness, itching, and pain during intercourse.

4. Stabilizes Mood Swings

  • Reduces Anxiety, stabilizes mood swings, and has been shown to improve symptoms of depression.

5. Supports Cognitive Function

  • HT may help preserve verbal memory and focus when started during the perimenopausal window, although evidence is mixed and individualized.

6. Helps Maintain Bone Density

  • Estrogen helps prevent bone loss, reducing the risk of osteoporosis and fractures in postmenopausal years.

7. May Protect Heart Health (if started early)

  • When initiated before age 60 or within 10 years of menopause, HT may lower the risk of coronary artery disease.

8. Eases Joint and Muscle Aches

  • Many women report reduced joint stiffness and muscle pain, common complaints during perimenopause.

9. Enhances Skin Elasticity and Collagen

  • Estrogen may modestly improve skin thickness and hydration, reducing dryness and fine lines.

10. Improves Quality of Life

  • By alleviating multiple disruptive symptoms, HT can significantly improve overall well-being, energy, and daily functioning.


11. Supports Metabolic Function


  • Improved insulin sensitivity, muscle maintenance, and weight stability 


12. Significantly Reduces Major Health Risks


  •  Significantly reduces the risk of developing Coronary Artery Disease, Alzheimer's Dementia, and Osteoporosis. 
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