Know the Facts - Does Bioidentical Progesterone Pose a Cancer Risk?
Marshall Medical Group • May 19, 2025
Bioidentical progesterone, when used appropriately and under medical supervision, does not appear to pose the same cancer risk as synthetic progestins, particularly in the context of hormone replacement therapy (HRT) for menopausal women. Here's a more detailed breakdown:
1. Breast Cancer Risk
- Synthetic progestins (e.g., medroxyprogesterone acetate) have been associated with an increased risk of breast cancer when used in combination with estrogen.
- Bioidentical progesterone (e.g., micronized progesterone) has not been shown to significantly increase breast cancer risk and may even be associated with a lower risk compared to synthetic progestins.
- Study found that women using estrogen with micronized progesterone had a lower risk of breast cancer than those using estrogen with synthetic progestins.
2. Endometrial Cancer Risk
- Unopposed estrogen therapy {i.e., estrogen without progesterone) can increase the risk of endometrial {uterine) cancer.
- Adding bioidentical progesterone protects the endometrium in much the same way as synthetic progestins, reducing this cancer risk.
3. Other Cancers
There's limited evidence linking bioidentical progesterone to increased risk for other cancers {e.g., ovarian, colorectal), but overall data are still evolving and not conclusive.
Bottom Line:
Bioidentical progesterone is generally considered a safer option than synthetic progestins in terms of cancer risk, particularly for breast and endometrial cancers. However, it should still be:
- Prescribed and monitored by a qualified healthcare provider
- Tailored to individual risk factors and medical history
Microdosing GLP-1 taps into one of the body's master regulatory systems, impacting blood sugar, inflammation, the gut-brain axis, mitochondrial function, and even gene expression, all from a single peptide naturally made in your gut.
The American Health system is failing!
When considering Testosterone Replacement Therapy (TRT), one of the most common and anxiety-inducing questions men ask is: “Will testosterone cause prostate cancer?” This concern has deep roots in medical history, but today’s evidence paints a far more nuanced—and reassuring—picture.
The Latest Evidence: TRAVERSE Trial and Beyond The most rigorous clinical trial to date—In 2023, the TRAVERSE trial (Testosterone Replacement Therapy for Assessment of Long-Term Vascular Events and Efficacy Response in Hypogonadal Men)—was designed specifically to answer the cardiovascular question.
Here are 10 common symptoms of low testosterone (low T) in men, which can significantly impact both physical and mental health:
Here are 10 potential benefits of hormonal therapy (HT) for perimenopausal women, based on current clinical evidence and expert guidelines:
Here are 10 evidence-based ways to add healthy decades to your life—focusing not just on longevity, but also on quality of life:
Optimize Your Health, Energy, and Longevity with Data-Driven Wellness In today’s fast-paced world, more people are looking for ways to optimize their health, boost energy, and extend their lifespan—not just by treating illness, but by proactively upgrading the way their body and mind function. That’s where biohacking comes in. At Marshall Medical Group, we help our patients take control of their own biology through a personalized, science-backed approach to wellness. From advanced diagnostics and targeted supplements to customized fitness and nutrition plans, biohacking is about leveraging data and innovation to help you look, feel, and perform at your best—every day. Whether you're new to the concept or already tracking your biometrics, this guide will help you understand what biohacking is, how it works, and how concierge medicine can support you in achieving peak health.
As a busy executive or high-net-worth individual, your time is your most valuable asset. Between demanding work schedules, travel, and personal commitments, managing your health can often take a backseat—leading to unnecessary stress, wasted time, and frustration. Fortunately, concierge medicine offers a smarter, more efficient healthcare solution that can enhance both your work-life balance and your overall well-being. At Marshall Medical Group, we understand the unique challenges of balancing a high-powered career with personal health. With personalized care that focuses on convenience, efficiency, and high-touch service, concierge medicine provides an elevated healthcare experience tailored to your needs. Let’s explore how concierge medicine can help you reduce stress, streamline your healthcare, and ultimately reclaim your time and peace of mind.
For today’s business executives and frequent flyers, travel is a way of life. But with long flights, changing time zones, unfamiliar food, and varying healthcare standards around the world, staying healthy on the go can be a challenge. At Marshall Lifestyle Medicine, we offer comprehensive travel medicine services designed specifically for busy professionals. Whether you’re preparing for a trip across the country or halfway around the globe, our concierge care model ensures you have direct access to your physician —anytime, anywhere. Let’s explore how concierge medicine can support your travel lifestyle and what steps you can take to protect your health while away from home.